Grafted Eyes of Young and Old Adult Salamanders (Amblystoma Punctatum) Showing Return of Vision *
نویسندگان
چکیده
These experiments are part of a series which the senior author has been making on the grafted vertebrate eye in fishes, amphibians, and mammals. In all of the vertebrates studied the eyes were completely excised and then eith-er reimplanted in the same orbit or transplanted to the denuded orbit of another host. In placing the graft, care was taken to re-establish the normal orientation. In the forms so far studied in this laboratory, it may be briefly stated that the grafted functional eyes of fishes and mammals are somewhat alike in the fact that the retina and optic nerve undergo extensive degeneration followed by no regeneration, thus inhibiting return of function. In certain types of amphibians restitution in the grafted eye provides quite a different story. In this group alone more than 1000 grafted functional eyes have been studied in animals of various species and at various stages. 9 10, 11, 12, 13, 14, 16, 17, 19, 20, 21 In the anurans (frogs) the grafted tadpole or larval eyes have shown that the retina survives the operation, but that the optic nerve possesses no power for regeneration. On the other hand, in urodeles (salamanders) the optic nerve and the retina have a great capacity for regeneration. This was shown in the larvae of the species, Amblystoma punctatum,8' 20 and in other species of adult salamanders referred to in the literature already mentioned. Eyes can be exchanged with success in one16 or both8 directions between animals of different species. In one type (adult Triturus viridescens) return of vision can even be obtained repeatedly in the same eye after several transplantations. A colored motion picture has been recently prepared recording these experiments.12 The present report gives
منابع مشابه
Return of Vision in Larval Eyes Exchanged between Amblystoma Punctatum and the Cave Salamander, Tryphlotriton Spelaeus.
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The Effect of Replantation, Lens Removal, and Optic Nerve Section of the Eye of the Salamander (Triturus Viridescens) *
In 1885 Bradford replaced the atrophied eye of a 35-year-old sailor with the eyeball of a rabbit and reported a good cosmetic result without return of vision. Two years later May attempted, without success, to duplicate this result and conduded that the whole eyeball was too large a mass to transplant with the hope of retaining vitality in all of its parts. Gradually work turned from man to the...
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 15 شماره
صفحات -
تاریخ انتشار 1943